تأثیر هشت هفته تمرین هوازی به همراه مصرف جلبک کلرلا بر مقادیر پلاسمایی آنزیم پاراکسوناز-1 و لیپید هیدروپراکسید در رت‌های نر دیابتی‌شده

Introduction: The aim of this research was to investigate the effect of eight weeks of aerobic exercise and Chlorella supplementation on paraoxonase-1 and lipid hydroperoxide in Wistar rats with type 2 diabetes. Methods: The present study is an experimental research. 50 male Wistar rats with an average weight of 220±10 g were divided into 5 groups of normal control, diabetic control, diabetes + Chlorella supplementation, diabetes + aerobic exercise and combined (diabetes + Chlorella supplementation + aerobic exercise). The subjects were studied throughout an eight-week period and the levels of paraoxonase 1 and Lipid hydroperoxide were measured after this period. The data were analyzed using one-way ANOVA and Tukey’s post-hoc test. Results: The results showed significant differences between the groups in terms of paraoxonase-1 level (P=0.001). Comparisons between the Chlorella supplementation and aerobic exercise groups (P=0.001), Chlorella supplementation and combined groups (P=0.001), and aerobic exercise and combined groups (P=0.007) also showed significant differences. Also, there were significant differences between the groups in terms of Lipid hydroperoxide (P=0.001) as significant differences between the Chlorella supplementation and aerobic exercise groups (P=0.005), the Chlorella supplementation and combined groups (P=0.001) and the aerobic exercise and combined groups (P=0.029). Conclusion: Eight weeks of aerobic training and eight weeks of taking Chlorella can reduce Lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes. However, a combination of exercise and Chlorella supplementation leads to better results.